In 1312, Goa came under the governance of the Delhi Sultanate. However, the kingdom's grip on the region was weak, and by 1370 they were forced to surrender it to Harihara I of Vijayanagara. The Vijayanagara monarchs held on to the territory for the next hundred years until 1469, when it was appropriated by the Bahmani sultans of Gulbarga. After the dynasty crumbled, the area came under the hands of the Adil Shahis of Bijapur who made Velha Goa their auxiliary capital.

In 1498, Vasco da Gama became the first European to set foot in India through a sea route, landing in Calicut (Kozhikode) in Kerala, followed by an arrival in what is now known as Old Goa. The Portuguese arrived with the intention of setting up a colony and seizing complete control of the spice trade from other European powers after traditional land routes to India were closed by the Ottoman Turks. Later, in 1510, Portuguese admiral Afonso de Albuquerque defeated the ruling Bijapur kings with the help of a local ally, Timayya, leading to the establishment of a permanent settlement in Velha Goa (or Old Goa). The Portuguese intended it to be a colony and a naval base, distinct from the fortified enclaves established elsewhere along India's coasts.